Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5834558 | Journal of Ethnopharmacology | 2016 | 20 Pages |
Abstract
Clinical practice and animal experiments indicate that TCM formulas provide a definite therapeutic effect on osteoporosis. The active constituents in TCM formulas are diverse in chemical structure, and include flavonoids, lignans, saponins and iridoid glycosides. Antiosteoporotic mechanism of TCM formulas and herbs involves multi regulatory pathways, such as Wnt/β-catenin, BMP/Smad, MAPK pathway and RANKL/OPG system. Phytochemicals from TCM formulas and their compositional herb medicines offer great potential for the development of novel antiosteoporotic drugs. The active ingredients in TCM formulas can be developed in combination as potent drugs, which may exhibit better antiosteoporotic effects compared to the individual compound.
Keywords
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Pharmacology, Toxicology and Pharmaceutical Science
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Authors
Nai-Dan Zhang, Ting Han, Bao-Kang Huang, Khalid Rahman, Yi-Ping Jiang, Hong-Tao Xu, Lu-Ping Qin, Hai-Liang Xin, Qiao-Yan Zhang, Yi-min Li,