| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5835547 | Journal of Ethnopharmacology | 2015 | 7 Pages |
Abstract
Modified sini decoction (MSND) improved the liver function, reduced the hepatic pathological damage and prolonged the survival time of rats with ALF induced by d-GalN. MSND was more effective than SNMC. These effects were most likely mediated by the inhibition of the HMGB1/TLR4/NF-κB pathway, the downregulation of the mRNA expression of Caspase-3 and the upregulation of PCNA expression.163
Keywords
NF-κBPCNAD-GalNHE stainingTBILALFTRL4HMGB1ALTRT-PCRALBd-GalactosamineH&EASTAspartate aminotransferaseAlanine aminotransferaseAlbuminProliferating Cell Nuclear AntigeninflammationApoptosisprothrombin timeLiver functionnuclear factor kappa BAcute liver failureHematoxylin and EosinHigh-mobility group box 1 proteintotal bilirubinCHECholinesteraseToll-like receptor 4
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Authors
Jianxing Luo, Yang Zhang, Xiaoyu Hu, Sen Zhong, Guo Chen, Yanyan Wang, Wu Lin, Cheng Yi, Hong Zhu,