Effects of Gelsemium sempervirens L. on pathway-focused gene expression profiling in neuronal cells

Effects of Gelsemium sempervirens on human neurocytes. Treatment of SHSY-5Y neurocytes for 24 h with Gelsemium sempervirens 2c dilution leads to a prevailing gene expression down regulation of a series of neuronal receptors and regulators. Among the genes investigated by the RT-PCR array, the most significant down regulated gene is the G-protein coupled receptor PROKR2 of prokineticin 2 (PK2). The decrease of the receptor and associated transduction pathways may eventually lead to increase of GABA-A receptor function, thus decreasing cell excitability.262