Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5836690 | Journal of Ethnopharmacology | 2014 | 5 Pages |
Abstract
Effects of Gelsemium sempervirens on human neurocytes. Treatment of SHSY-5Y neurocytes for 24Â h with Gelsemium sempervirens 2c dilution leads to a prevailing gene expression down regulation of a series of neuronal receptors and regulators. Among the genes investigated by the RT-PCR array, the most significant down regulated gene is the G-protein coupled receptor PROKR2 of prokineticin 2 (PK2). The decrease of the receptor and associated transduction pathways may eventually lead to increase of GABA-A receptor function, thus decreasing cell excitability.262
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Authors
Debora Olioso, Marta Marzotto, Elisabetta Moratti, Maurizio Brizzi, Paolo Bellavite,