| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5837065 | Journal of Ethnopharmacology | 2013 | 9 Pages |
Abstract
Cell cycle distribution of leukemia CCRF-CEM cells treated with plant extracts and doxorubicin at their IC50 values for 72Â h: All the four plant extracts as well as doxorubicin induces apoptosis and considerably altered the distribution of different phases, with time-dependent increase of sub-G0/G1 phase cells. Upon 72Â h treatment, the extracts from Echinops giganteus and Piper capense induced cell cycle arrest in G0/G1, whilst those from Imperata cylindrica and Xylopia aethiopica induced arrest between Go/G1 and S phases.235
Keywords
APAf-1H2DCFH-DAPiper capenseImperata cylindricaH2DCFXylopia aethiopicaddH2OJC-1dichlorofluoresceinVCCTLCIC50MMPDcfMDRDCM2′,7′-dichlorodihydrofluorescein2′,7′-dichlorodihydrofluorescein diacetate5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolylcarbocyanine iodideDMSOROSOxygenated waterdouble distilled waterATPapoptotic protease activating factor-1SpicesMelting pointsCell cycle distributiondimethylsufoxideDichloromethaneCytotoxicityVINMultidrug resistantH2O2VinblastineMitochondrial membrane potentialCameroonColumn chromatographythin layer chromatographyReactive oxygen species
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Authors
Victor Kuete, Louis P. Sandjo, Benjamin Wiench, Thomas Efferth,