Huang-Lian-Jie-Du-Decotion induced protective autophagy against the injury of cerebral ischemia/reperfusion via MAPK-mTOR signaling pathway

Article ID	Journal	Published Year	Pages	File Type
5837072	Journal of Ethnopharmacology	2013	11 Pages	PDF

Keywords

ECL ERK CCA GSSG TTC BCA WST-1 CMC-Na t-PA DTNB PIP3 lCBF Laser Doppler flow meter PDK1 mTORC1 MCAO i.g.TBS-T LC3 ATG LDF IPC ECA phosphatidylinositol (3,4,5) trisphosphate mLST8 PI3K MCA Autophagy related genes Jnk ICA PIP2 MDA mSIN1 HLJDD mTOR GSH S6K T-SOD 2,3,5-triphenyltetrazolium chloride 5,5′-dithiobis-(2-nitrobenzoic acid)BSA GSH-Px I/R MAPK p70 ribosomal S6 kinase ischemic preconditioning ROS S.D.Tris-buffered saline containing 0.1% Tween-20 w/v Akt Autophagy sodium dodecyl sulfate-polyacrylamide gel electrophoresis SDS-PAGE standard deviation middle cerebral artery occlusion Middle cerebral artery occlusion (MCAO)ischemia/reperfusion enhanced chemiluminescence bicinchoninic acid ANOVA one-way analysis of variance intragastric administration Rictor microtubule-associated protein1 light chain 3 total superoxide dismutase Stroke middle cerebral artery external carotid artery internal carotid artery common carotid artery figure Fig.Phosphatidylinositol 3-kinase Phosphatidylinositol (4,5) bisphosphate Tissue-plasminogen activator malondialdehyde NADH Nitric oxide mammalian target of rapamycin hematoxylin–eosin protein kinase B Protein kinase B (AKT)Mitogen-activated protein kinase (MAPK)mitogen-activated protein kinase Pten carboxymethyl cellulose sodium salt extracellular signal-regulated kinases Glutathione glutathione disulfide glutathione peroxidase Reactive oxygen species

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Huang-Lian-Jie-Du-Decotion induced protective autophagy against the injury of cerebral ischemia/reperfusion via MAPK-mTOR signaling pathway

Authors

Peng-Ran Wang, Jun-Song Wang, Chao Zhang, Xing-Fang Song, Na Tian, Ling-Yi Kong,