| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5837093 | Journal of Ethnopharmacology | 2013 | 36 Pages |
Abstract
The topical application of extract(s) of Shorea robusta young leaves, and its isolated compounds ursolic acid and bergenin may promote wound healing activity in Excision Incision and Dead space wound models in rats, probably by inhibiting or modulating some mediators and inflammatory cytokines like TNF-α and PGE2. The tissue histology of wounded and treated (extracts or compounds) animals showed complete epithelialisation with increased collagenation. Hence this study provides the pharmacological evidence of the folk use of Shorea robusta young leaves, for wound healing.198
Keywords
THPHuman acute monocytic leukemia cell lineTLCInterferon- γPGERBCiNOSRPMIIFN-γWBCphorbol 12-myristate 13-acetateT helperUSPShorea robustaEpithelialisationNS-398British PharmacopoeiaLPSCOXFBSnuclear magnetic resonanceDMSOPMAMTTcyclooxygenaseEthnomedicineTensile strengthWound HealinginterleukinNMRtumour necrosis factor-αDimethyl sulfoxidefetal bovine seruminducible nitric oxide synthaseFTIRMass spectrometryFourier transform infrared spectroscopyaqueous extractMethanol extractTNF-αlipopolysaccharideInfraredRoswell Park Memorial Institute mediumNitric oxideHemoglobinprostaglandinTLC, Thin layer chromatography
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Authors
Hemanta Mukherjee, Durbadal Ojha, Yogesh P. Bharitkar, Soma Ghosh, Supriya Mondal, Sudipta Kaity, Shanta Dutta, Amalesh Samanta, Tapan K. Chatterjee, Sekhar Chakrabarti, Nirup B. Mondal, Debprasad Chattopadhyay,