Methanol extract of Osbeckia stellata suppresses lipopolysaccharide- and HCl/ethanol-induced inflammatory responses by inhibiting Src/Syk and IRAK1

Article ID	Journal	Published Year	Pages	File Type
5838047	Journal of Ethnopharmacology	2012	8 Pages	PDF

Abstract

Os-ME has potent anti-inflammatory activity mediated by NF-ÃªB and AP-1 inhibitory property that are linked to the suppression of Src/Syk and IRAK1 activation.125

Keywords

IRAK1 iNOS ERK RT-PCR PGE2 Melastomataceae AP-1 MYD88 TLR IKK Jnk TRAF6 COX LPS MAP kinase kinase TAK1 PDK1 PI3K NF-κB c-Jun N-terminal kinase IκBα kinase MAPK MKK inducible NO synthase TRIF cyclooxygenase Akt Anti-inflammatory effects enzyme immunoassay EIA TIR-domain-containing adapter-inducing interferon-β Syk Enzyme-linked immunosorbent assay ELISA tumor necrosis factor-alpha Toll-like receptor spleen tyrosine kinase TNF-α nuclear factor-kappaB Phosphoinositide 3-kinases lipopolysaccharide Nitric oxide Phosphoinositide-dependent kinase-1 Reverse transcriptase-polymerase chain reaction activator protein-1 protein kinase B mitogen activated protein kinase Prostaglandin E2 interleukin-1 receptor-associated kinase 1 extracellular signal-related kinase

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Methanol extract of Osbeckia stellata suppresses lipopolysaccharide- and HCl/ethanol-induced inflammatory responses by inhibiting Src/Syk and IRAK1

Authors

Yanyan Yang, Sang Hyun Moh, Tao Yu, Jae Gwang Park, Deok Hyo Yoon, Tae Woong Kim, Seong Hwan Kim, Sukchan Lee, Sungyoul Hong, Jae Youl Cho,