Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5838284 | Journal of Ethnopharmacology | 2012 | 9 Pages |
Abstract
Our results indicate caspase-mediated activation of the mitochondrial death pathway plays a critical role in the FRAP-induced apoptosis of HeLa cells and that FRAP inhibits the in vivo tumor growth of HeLa xenograft mice.
Keywords
ΔΨmPARPDAPIBcl-xLGAPDHBcl-24′,6-diamidino-2-phenylindoleDMSOMTTBaxApoptosisDimethyl sulfoxideB-cell lymphoma 2B-cell lymphoma-extra largeMitochondriapolymerase chain reactionPCRMitochondria membrane potentialBcl-2 Associated X proteinPropidium iodidepoly (ADP-ribose) polymeraseCaspaseshigh performance liquid chromatographyHPLCcaspaseglyceraldehyde 3-phosphate dehydrogenase
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Authors
Hye-Kyung Ju, Heon-Woo Lee, Kyung-Sook Chung, Jung-Hye Choi, Jin-Gyeong Cho, Nam-In Baek, Hae-Gon Chung, Kyung-Tae Lee,