| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5838934 | Journal of Ethnopharmacology | 2011 | 8 Pages |
Abstract
AqF from Costus spiralis reduces the calcium entry in myocardial cells as showed by its effect on the Bowditch phenomenon and on the positive inotropic effect produced by both BAY K8644 and isoproterenol. Direct measurements of the L-type calcium current (ICa, L) as well as of the intracellular free calcium determined by the fluorescence of FLUO 4AM (F/F0) confirmed such hypothesis.
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Authors
Raquel Moreira Britto, André Luiz Santos, Jader Santos Cruz, Antonio Nei Santana Gondim, Sandra Lauton-Santos, Aline Lara, Silvia Guatimosim, Carla Maria Lins Vasconcelos, Charles dos Santos Estevam, Antonio Santos Dias, Evaleide Diniz Oliveira,