Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5839301 | Journal of Ethnopharmacology | 2011 | 10 Pages |
Abstract
Ethonopharmacological relevanceLung cancer is one of the most lethal cancers in terms of mortality and incidence worldwide. Despite intensive research and investigation, treatment of lung cancer is still unsatisfactory due to adverse effects and multidrug resistance. Recently, herbal drugs have been recognized as one of attractive approaches for lung cancer therapy with little side effects. Furthermore, there are evidences that various herbal medicines have proven to be useful and effective in sensitizing conventional agents, prolonging survival time, preventing side effects of chemotherapy, and improving quality of life (QoL) in lung cancer patients.Aim and methods of the studyNevertheless, the underlying molecular targets and efficacy of herbal medicines in lung cancer treatment still remain unclear. Thus, we reviewed traditionally used herbal medicines and their phytochemicals with antitumor activity against lung cancer from peer-reviewed papers through Scientific Database Medline, Scopus and Google scholar.ConclusionsWe suggest that herbal medicines and phytochemicals can be useful anti-cancer agents for lung cancer treatment by targeting molecular signaling involved in the regulation of angiogenesis, metastasis and severe side effects, only provided quality control and reproducibility issues were solved.
Keywords
MDRPDGFGSPbFGFTCSRCTDPPHERKHUVECCOXECMP-gpMMPNF-κBPARPTNFTGFCREBEGFRBBSKEdihydroartemisininMRPRTOGQOLQuality of lifeP-glycoproteinPFsROSrandomized-controlled trialcyclooxygenaseAngiogenesisUrsolic acidcAMP response element-bindingMolecular targetsPAIplasminogen activator inhibitorProgression free survivalSCLCTrichosanthinApoptosisHerbal medicineDHATIMPCAMLung cancerNSCLCSmall cell lung cancerNon-small cell lung cancerHuman umbilical vein endothelial cellSolamarginecomplementary and alternative medicinetumor growth factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)platelet-derived growth factorbasic fibroblast growth factortumor necrosis factornuclear factor-kappaBPhytochemicalExtracellular matrixmatrix metalloproteinaseMultidrug resistanceTissue inhibitor of metalloproteinaseMonacolin KGrape seed proanthocyanidinCRPextracellular signal-related kinaseRadiation Therapy Oncology GroupReactive oxygen speciesEpidermal growth factor receptor
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Authors
Soo-Jin Jeong, Wonil Koh, Bonglee Kim, Sung-Hoon Kim,