Kudzu root: Traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases

Article ID	Journal	Published Year	Pages	File Type
5840202	Journal of Ethnopharmacology	2011	24 Pages	PDF

Abstract

Kudzu root (Gegen in Chinese) is the dried root of Puerarialobata (Willd.) Ohwi, a leguminous vine native to South East Asia, which has been used as a traditional Chinese medicine for the treatment of fever, acute dysentery, diarrhoea, thirst, diabetes and cardiovascular diseases for thousands of years. The present review summarises the traditional applications, phytochemistry, pharmacological activities, toxicology, quality control and potential interactions with conventional drugs from both English and Chinese literatures.

Keywords

STAT3 NF-κB 5-HT CYP7A1 CyP NADPH HO-1 HUVECS ICAM-1 EPO Bcl-2 TCM iNOS MMP-2 PPARγ hsp70 eNOS ADP HEK293 ACE2 MPTP OGD JAK2 NMDA MCAO APV STZ HIF-1α 1-methyl-4-phenylpyridinium PKC CMM DNQX CYP51 AT1 SGLT HMG-CoA Heme oxygenase-1 GLUT dl-2-amino-5-phosphonovaleric acid KATP RAGE PLR mKATP PC12 RCT T2DM VCAM-1 USDA HSPG VLDL Janus Kinase 2 TIMP-2 XIAP ODQ NRF-2 N-nitro-l-arginine IUCN Pueraria lobata Pueraria thomsonii Angiotensin II type I receptor L-NNA Aβ25-35 Puerariae Lobatae Radix NF-E2 related factor-2 Mitochondrial ATP-sensitive potassium channel ATP-sensitive K channel hypoxia-inducible factor 1 α 3-hydroxy-3-methylglutaryl coenzyme A 7α-hydroxylase BKCa l-NAME MPP+inducible NOS PTr ROS β-Amyloid adenosine diphosphate Angiotensin-converting enzyme 2 International Union for Conservation of Nature erythropoietin reactive oxidative stress streptozotocin γ-aminobutyric acid kainic acid mitochondrial permeability transition pore endothelial NO synthase middle cerebral artery occlusion oxygen/glucose deprivation Cardiovascular diseases Diabetes Glucose transporter Gegen United States Department of Agriculture Type 2 diabetes mellitus CVD CAM World Health Organisation Human umbilical vein endothelial cells pheochromocytoma cells Age Metabolic syndrome Cytochrome P450 Shr traditional Chinese medicine complementary and alternative medicine Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)TNF-α nuclear factor kappa-light-chain-enhancer of activated B cells LAD lactate dehydrogenase LDH very low density lipoprotein matrix metalloproteinases-2 Chinese materia medica Signal transducers and activators of transcription 3 advanced glycation end-products spontaneous hypertensive rats vascular cell adhesion molecule-1 Nitric oxide nicotinamide adenine dinucleotide phosphate Heat shock protein70 Protein kinase C left anterior descending Large-conductance calcium-activated potassium channel human embryonic kidney 293 WHO GABA Peroxisome proliferator-activated receptor gamma Receptor for advanced glycation end-products