| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5840415 | Journal of Pharmacological and Toxicological Methods | 2016 | 6 Pages |
Abstract
iCell Neurons represent a new cellular model to characterize GABAergic compounds using automated patch clamp. These cells have excellent representation of cellular GABAA receptor distribution that enable determination of total small molecule efficacy and affinity as measured by cell membrane current change.
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Authors
Nina Y. Yuan, Michael M. Poe, Christopher Witzigmann, James M. Cook, Douglas Stafford, Leggy A. Arnold,