Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5840417 | Journal of Pharmacological and Toxicological Methods | 2016 | 8 Pages |
Abstract
The positive results obtained with the IQ-CSRC study require additional confirmation with threshold QTc-positive and negative drugs and established QTc prolongers producing both increases and decreases in heart rate. In the future, similar studies should also adopt and validate innovative proarrhythmic metrics, in addition to, or instead of, the traditional proarrhythmic surrogate of QTc, to assess the proarrhythmic safety of candidate drugs.
Keywords
cSrcICaLThorough QT studyIKrCIPAINaFINaLHERGMADe-rIRTPOCTQTFDATPEIUTHTPCmaxhiPSC-CMsComprehensive in vitro Proarrhythmia AssayProof of ConceptECGelectrocardiogramlate sodium currentHigh throughputmaximal plasma concentrationFood and Drug AdministrationFIHPersSADPharmacodynamicsPharmacokineticsExposure-responseCardiac action potentialhuman ether-à-go-go-related geneWorking group
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Authors
Icilio Cavero, Henry Holzgrefe, Mike Clements,