| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5840420 | Journal of Pharmacological and Toxicological Methods | 2016 | 9 Pages |
Abstract
IKs inhibition increased the QTc prolonging effect of IKr inhibitors in a super-additive (synergistic) manner, and the QTc interval was superior to other proarrhythmia biomarkers measured in sinus rhythm in isolated guinea pig hearts. The effect of catecholamines on the QTc facilitated differentiation between IKr and IKs inhibitors. Thus, QTc measurement in Langendorff perfused guinea pig hearts with pharmacologically attenuated repolarization reserve and periodic catecholamine perfusion seems to be suitable for preclinical proarrhythmia screening.
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Authors
Péter Kui, Szabolcs Orosz, Hedvig Takács, Annamária Sarusi, Norbert CsÃk, Ferenc Rárosi, Csongor CsekÅ, András Varró, Julius Gy. Papp, Tamás Forster, Attila S. Farkas, András Farkas,