Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5840423 | Journal of Pharmacological and Toxicological Methods | 2016 | 23 Pages |
Abstract
We have investigated the stability towards repeated testing and the effect of i.v. glyceryl trinitrate infusion to awake rats in three behavioral assays. Of the assays evaluated, only light sensitivity was capable of detecting changes after glyceryl trinitrate infusion but, this was not repeatable. Thus, the infusion of a low dose glyceryl trinitrate to concious rats together with the chosen behavioral tests is not a robust setup for studying immediate GTN induced headache behavior in rats.
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Authors
Sarah L.T. Christensen, Steffen Petersen, Dorte B. Sørensen, Jes Olesen, Inger Jansen-Olesen,