PKPD modelling of PR and QRS intervals in conscious dogs using standard safety pharmacology data

Article ID	Journal	Published Year	Pages	File Type
5840440	Journal of Pharmacological and Toxicological Methods	2016	11 Pages	PDF

Abstract

Baseline and drug-induced effects on QRS and PR intervals can be effectively described with PKPD models using routine data, providing quantitative safety information to support drug discovery and development.

Keywords

QTc LLQ hNav1.5 PKPD modelling Quinidine (PubChem CID: 441074)Verapamil (PubChem CID: 2520)BSV HERG ppb AIC LC–MS/MS Plasma protein binding Safety assessment electrocardiogram ECG Cardiac safety PR interval blq lower limit of quantification pharmacodynamic pharmacokinetic cardiovascular QRS complex Akaike information criterion Methods Cardiac conduction M3 receptor

Related Topics

Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology

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PKPD modelling of PR and QRS intervals in conscious dogs using standard safety pharmacology data

Authors

Linnéa Bergenholm, Teresa Collins, Neil D. Evans, Michael J. Chappell, Joanna Parkinson,