Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5840443 | Journal of Pharmacological and Toxicological Methods | 2016 | 12 Pages |
Abstract
We describe protocols for and illustrative data from the assessment of murine cardiac responses to acute and sustained β-adrenergic stimulation in vivo, which would be of value in determining the impact of genetic or pharmacological interventions on such responses. Additionally, our data indicate that acute dobutamine stimulation unmasks early signs of LV dysfunction in the remodelled heart, even at a stage when basal function is enhanced.
Keywords
LVPWLVIDi.p.s.cβ-AREnd-diastolicIVSDOBβ-AdrenoceptorISOIsoprenalineLeft ventricularVolVolumeDobutamineintraperitonealleft ventricular posterior wallanterior wallsubcutaneousInterventricular septumtibia lengthleft ventricular internal diameterMethodsHeart weightEnd-systolicejection fractionfractional shortening
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Authors
Sarah-Lena Puhl, Kate L. Weeks, Antonella Ranieri, Metin Avkiran,