Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5840453 | Journal of Pharmacological and Toxicological Methods | 2015 | 8 Pages |
Abstract
The current study shows group housing to be technically possible during non-invasive ECG recording, resulting in lower resting heart rates and small improvements in sensitivity of detection of drug-induced effects. Given the psychological benefits of group housing for NHPs, it is a refinement that should be considered when conducting ECG assessments in NHP toxicology studies.
Keywords
NHPData Sciences InternationalDSIANCOVAAAALACJacketed external telemetryQT intervalECGelectrocardiogramAssociation for Assessment and Accreditation of Laboratory Animal Careanalysis of covarianceanalysis of varianceANOVAJetSafety pharmacologyHeart rateconfidence intervalSingle housingGroup housingICHMethodsMoxifloxacinnon-human primateNon-human primatesInternational Conference on Harmonisation
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Guozhen Xing, Jing Lu, Miaomiao Hu, Shaodong Wang, Li Zhao, Weijun Zheng, Jason Schofield, Karen Oldman, Debbie Adkins, Hong Yu, Stefan Platz, Jin Ren, Matthew Skinner,