14th Annual Meeting of the Safety Pharmacology Society: Threading through peripheral and central nervous system presentations

Article ID	Journal	Published Year	Pages	File Type
5840465	Journal of Pharmacological and Toxicological Methods	2015	40 Pages	PDF

Abstract

There were salient points arising from the CNS presentations but from a pharmacological point of view we note in particular that safety pharmacology should move to routinely apply polysomnographic technologies to determine whether candidate drugs exert deleterious effects on sleep quality and architecture that may markedly decrease quality of life and impair cognitive functions, including alertness and reaction time.

Keywords

ADF Cmax SDB DRG ICA SPS Trp API EMA Aβ PTZ CRPS RDI APP aHI EOG NMDA N-methyl-d-aspartate qEEG NREM REM DPN NFT tmax CPAP SWS BACE ASIC HRQOL NIA VLPO PiB AASM NAPA NOEL FOB IASP DN4 PLMD QSART FDA MPQ investigational new drug application Pittsburgh compound-B AUC Quantitative EEG NPs AAN Diabetic polyneuropathy qst t1/2 Obstructive sleep apnea (OSA)obstructive sleep apnea Central sleep apnea Apoe apolipoprotein E European Medicines agency American Academy of Neurology American Academy of Sleep Medicine Alzheimer's Disease Neuroimaging Initiative Periodic limb movement disorder mild cognitive impairment Sleep disturbances EFNS gamma-aminobutyric acid Electroencephalogram electrooculogram EMG electromyogram ECG electrocardiogram Extended release International Association for the Study of Pain ind CSA AIDS Functional observational battery Osa MEG Alzheimer's disease Independent component analysis Quantitative Sensory Testing Quantitative sudomotor axon reflex test fMRI functional magnetic resonance imaging Positron emission tomography rapid eye movement sleep Non-REM sleep slow wave sleep NICE Safety pharmacology CNS Food and Drug Administration BBB blood brain barrier CRPS, Complex Regional Pain Syndrome acquired immune deficiency syndrome central nervous system apnea/hypopnea index Respiratory disturbance index FIH Pharmacokinetics European Federation of Neurological Societies Continuous positive airway pressure Transmural pressure Cerebrospinal fluid CSF magnetoencephalography Neuropathic pain scale ICH area under the curve Active Pharmaceutical Ingredient National Institute for Health and Clinical Excellence National Institute on Aging neurofibrillary tangles EEG Ventrolateral preoptic nucleus MCI No observed effect level PET Abuse potential transient receptor potential McGill Pain Questionnaire Pentylenetetrazole PEO acid-sensing ion channels ADNI health related quality of life GABA