Article ID Journal Published Year Pages File Type
5840939 Journal of Pharmacological and Toxicological Methods 2015 7 Pages PDF
Abstract
Compared to evoked field potentials, spontaneous spike activity in the hippocampal CA1 region appears to be a significantly more sensitive parameter for functional electrophysiological analysis of drug induced Ach-mediated effects. This finding may supplement existing models for detection and prediction of drug-related adverse effects like seizure liability already during early development stages.
Related Topics
Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology
Preview
Analysis of spontaneous hippocampal activity allows sensitive detection of acetylcholine-mediated effects
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