| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5840940 | Journal of Pharmacological and Toxicological Methods | 2015 | 7 Pages |
Abstract
Two novel methods were developed to stimulate B cells in rat whole blood, that have the potential to be used to support drug discovery efforts in the therapeutic targeting of B cells. Furthermore, we pharmacologically validated these whole blood assays using highly selective inhibitors of BTK, SYK, and PI3Kδ, signaling kinases which are downstream of the B cell receptor.
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Authors
John Shin, Marianne Spatz, Philip Brandish, Francois Gervais, Jie Zhang-Hoover, Erica Leccese, Alexandra Hicks,