| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5840973 | Journal of Pharmacological and Toxicological Methods | 2015 | 10 Pages |
Abstract
Preclinical PKPD analysis can increase the confidence in the quantification of small QTc effects and potentially allow reducing the number of animals while maintaining the required study sensitivity. This underscores the value of PKPD modeling in preclinical safety testing.
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Authors
Verena Gotta, Frank Cools, Karel van Ammel, David J. Gallacher, Sandra A.G. Visser, Frederick Sannajust, Pierre Morissette, Meindert Danhof, Piet H. van der Graaf,