Article ID Journal Published Year Pages File Type
5840975 Journal of Pharmacological and Toxicological Methods 2015 7 Pages PDF
Abstract
These data suggest that this method might be a valuable tool for investigating the thermoregulatory and locomotor effects of different drugs at spinal level; however, the prolonged effects of intrathecal vehicle injections should also be considered. The results point out that morphine is a very potent hyperthermic drug that may act primarily on the efferent limb of thermoregulation, at least partially, via an indirect NMDA-receptor mediated action mechanism.
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Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology
Authors
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