Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5840975 | Journal of Pharmacological and Toxicological Methods | 2015 | 7 Pages |
Abstract
These data suggest that this method might be a valuable tool for investigating the thermoregulatory and locomotor effects of different drugs at spinal level; however, the prolonged effects of intrathecal vehicle injections should also be considered. The results point out that morphine is a very potent hyperthermic drug that may act primarily on the efferent limb of thermoregulation, at least partially, via an indirect NMDA-receptor mediated action mechanism.
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Authors
A. Safrany-Fark, Z. Petrovszki, G. Kekesi, C. Keresztes, G. Benedek, G. Horvath,