| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5840977 | Journal of Pharmacological and Toxicological Methods | 2015 | 6 Pages |
Abstract
We confirmed that the system provides valuable data about intracellular Ca2Â + dynamics by allowing simultaneous measurements and sequential addition of compounds in adherent cells. The decrease in mitochondrial Ca2Â + loading following CPA-induced ER depletion in TRPC1-silenced Huh7 cells suggests a possible role of TRPC1 in hepatocellular carcinoma cell apoptosis. The system also enables the simultaneous measurement of isometric force and cytosolic Ca2Â + levels and promotes understanding vascular physiology and disease.
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Authors
Cigdem Selli, Yasemin Erac, Metiner Tosun,