| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5840983 | Journal of Pharmacological and Toxicological Methods | 2015 | 8 Pages |
Abstract
Evaluation of spontaneous convulsions provides information on the therapeutic window of a drug and the translational value of the approach is increased by the use of video-EEG. Tests based on provoked convulsions further complement the evaluation since they try to mimic high risk situations. Measurement of both spontaneous and provoked convulsions improves the evaluation of the pro-convulsant risk of novel pharmacological substances.
Keywords
Related Topics
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Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Elise Esneault, Guillaume Peyon, Christelle Froger-Colléaux, Vincent Castagné,