| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5840985 | Journal of Pharmacological and Toxicological Methods | 2015 | 5 Pages |
Abstract
The selected experimental conditions were viable to evaluate IC phagocytosis by neutrophils; they are also suitable to compare the efficiency of IC phagocytosis mediated by FcγR and CR classes of membrane receptors, alone or in combination. This method finds application in studies of (i) the receptor-specific phagocytic function of normal and pathogenic neutrophils as well as (ii) the impact of drugs and therapies on this essential effector function of neutrophils.
Keywords
DCFHreceptor for the Fc portion of IgGFcγRHBSSHEPESFITC2′,7′-dichlorodihydrofluorescein4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidBSADMSObovine serum albuminanalysis of varianceANOVADimethyl sulfoxideHank's balanced saline solutioncytochalasin Dfluorescein isothiocyanateimmune complexComplement receptor
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Authors
Everton O.L. Santos, Ana Elisa C.S. Azzolini, Yara M. Lucisano-Valim,