| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5840992 | Journal of Pharmacological and Toxicological Methods | 2014 | 5 Pages |
Abstract
The Straub tail response seems to be a specific sign for postsynaptic 5-HT1A receptor activation. In addition, the 5-HT2A receptor has more impact on the 5-HT syndrome than previously suggested. By inducing the broadest spectrum of signs, 5-HTP seems to be suitable as a positive control when investigating the 5-HT syndrome in mice. In summary, the murine model of the SS is a valid tool for preclinical studies to screen drugs and drug combinations for the risk to cause an SS in man.
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Authors
Robert Haberzettl, Heidrun Fink, Bettina Bert,