| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5841021 | Journal of Pharmacological and Toxicological Methods | 2013 | 8 Pages |
Abstract
The functional data indicate that hESC-CM are sensitive for detecting repolarization delay induced by hERG channel blockade, and AP prolongation correlated with potency in the hERG channel and IRH assays. However, hESC-CM were less sensitive for detecting depolarizing delay by Na+ channel blockers, and unable to detect delayed repolarization caused by IKs blockade.
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Authors
Yusheng Qu, BaoXi Gao, Mei Fang, Hugo M. Vargas,