| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5841023 | Journal of Pharmacological and Toxicological Methods | 2013 | 9 Pages |
Abstract
The in silico action potential assay demonstrates good predictive ability, and is suitable for very high-throughput use in early drug development. Adoption of such an assay into cardiovascular safety assessment, integrating ion channel data from routine screens to infer results of animal-based tests, could provide a cost- and time-effective cardiac safety screen.
Keywords
FLIPRpIC50ECVAMrapid delayed rectifier potassium currentIKrTorsades de pointesIC50IKSHERGTDPGSKGlaxoSmithKlineQT intervalECGelectrocardiogramCardiac safetyQSARQuantitative Structure Activity RelationshipCompound screeningConcentration for 50% InhibitionFLuorescence Imaging Plate ReaderMathematical modelEuropean Centre for the Validation of Alternative MethodsICHMethodsaction potentialIon channels
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Authors
Kylie A. Beattie, Chris Luscombe, Geoff Williams, Jordi Munoz-Muriedas, David J. Gavaghan, Yi Cui, Gary R. Mirams,