Multilevel pharmacological manipulation of adenosine-prostaglandin E2/cAMP nexus in the tumor microenvironment: A 'two hit' therapeutic opportunity

Article ID	Journal	Published Year	Pages	File Type
5843380	Pharmacological Research	2013	12 Pages	PDF

Keywords

E-prostanoid IP-10 MDSC NSAIDS Treg T helper ADP pKa cox2 PGE2 NECA DDA 2′,5′-dideoxyadenosine AMP 3LL CADO FOXP3 COX natural killer 2-chloroadenosine Adenosine adenosine-5′-triphosphate adenosine-5′-diphosphate adenosine-5′-monophosphate ATP adenylyl cyclase Ectonucleotidases interferon IFN interleukin TAM Non-steroidal anti-inflammatory drugs NSCLC Non-small cell lung cancer T regulatory cells Dendritic cells Myeloid-derived suppressor cells cyclo-oxygenase Chemo-immunotherapy Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)lymphokine-activated killer LAK Tumor-associated macrophages protein kinase A prostaglandin Lewis lung carcinoma Coxibs

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Multilevel pharmacological manipulation of adenosine-prostaglandin E2/cAMP nexus in the tumor microenvironment: A 'two hit' therapeutic opportunity

Authors

Muzammal Hussain, Aqeel Javeed, Muhammad Ashraf, Hou Yuzhu, Muhammad Mahmood Mukhtar,