Clarithromycin prevents human respiratory syncytial virus-induced airway epithelial responses by modulating activation of interferon regulatory factor-3

Article ID	Journal	Published Year	Pages	File Type
5843457	Pharmacological Research	2016	48 Pages	PDF

Keywords

MuV TLR IKK Ccl5 PRR RSV DPB MDA-5 LRI ERK IRF RIG-I MAVS TBK-1 RLR mAb IRF-3 NOD PBS TRAF TSLP NF-κB MAPK MOI TRIF STAT Monoclonal antibody Innate immunity interferon IFN TIR-domain-containing adapter-inducing interferon-β interleukin COPD Chronic obstructive pulmonary disease lower respiratory tract illness tumor necrosis factor-α TIR TANK-binding kinase 1 Toll-like receptor Dimethylsulfoxide CAM Airway epithelial cells interferon regulatory factor tumor necrosis factor receptor-associated factor TNF-α Nuclear factor-kappa B caspase activation and recruitment domain Cystic fibrosis Thymic stromal lymphopoietin Macrolide Signal transducer and activator of transcription Phosphate-buffered saline human respiratory syncytial virus Mumps virus diffuse panbronchiolitis mitochondrial antiviral-signaling protein mitogen-activated protein kinase Poly I:C polyinosinic-polycytidylic acid multiplicity of infection melanoma differentiation-associated gene 5 retinoic acid-inducible gene-I CARD Clarithromycin chemokine (C-C motif) ligand 5 extracellular signal-regulated kinase Toll/interleukin-1 receptor PRR, Pattern recognition receptor RIG-I-like receptors

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Clarithromycin prevents human respiratory syncytial virus-induced airway epithelial responses by modulating activation of interferon regulatory factor-3

Authors

Keisuke Yamamoto, Soh Yamamoto, Noriko Ogasawara, Kenichi Takano, Tsukasa Shiraishi, Toyotaka Sato, Ryo Miyata, Takuya Kakuki, Ryuta Kamekura, Takashi Kojima, Hiroyuki Tsutsumi, Tetsuo Himi, Shin-ichi Yokota,