| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5843607 | Pharmacological Research | 2011 | 8 Pages |
Abstract
⺠Role of endothelial nitric oxide synthase (eNOS) in the cardioprotection of ginseng was studied. ⺠Ginseng increased eNOS expression and inhibited anoxia/reoxygenation (A/R)-induced apoptosis in cultured cardiomyocytes. ⺠In vivo ginseng treatment increased myocardial eNOS expression in wild-type (WT) mice. ⺠Ginseng decreased myocardial apoptosis and infarct size following ischemia and reperfusion (I/R) in WT but not eNOSâ/â mice. ⺠We conclude ginseng protects the heart from I/R injury via upregulation of eNOS.
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Authors
Yan Wu, Xiangru Lu, Fu-Li Xiang, Edmund M.K. Lui, Qingping Feng,