AKT inactivation causes persistent drug tolerance to EGFR inhibitors

Article ID	Journal	Published Year	Pages	File Type
5843651	Pharmacological Research	2015	6 Pages	PDF

Keywords

FGFR1 Dusp6 dual specificity phosphatase 6 TKIs RTK Tyrosine kinase inhibitors (TKIs)HGF EGFR IGF-1R NRG1 FGF SCLC EMT RTK, Receptor tyrosine kinase Non-small-cell lung cancer Non-small-cell lung cancer (NSCLC)NSCLC Small cell lung cancer Hepatocyte growth factor fibroblast growth factor phosphatase and tensin homolog Drug resistance Tyrosine kinase inhibitors neuregulin 1 Pten Epithelial-mesenchymal transition insulin-like growth factor 1 receptor Epidermal growth factor receptor Fibroblast growth factor receptor 1

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AKT inactivation causes persistent drug tolerance to EGFR inhibitors

Authors

Osamu Tetsu, Janyaporn Phuchareon, David W. Eisele, Matthew J. Hangauer, Frank McCormick,