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Repeated administration of phytocannabinoid Δ9-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner

Article ID Journal Published Year Pages File Type
5843656 Pharmacological Research 2015 44 Pages PDF
Keywords
CB1RHU-210CP-55,940JWH-018AM-2201JWH-073WIN-55,212-2∆9-THC[35S]GTPγS∆9-tetrahydrocannabinolToleranceDownregulationCross-toleranceCannabinoidDesensitization
Related Topics
Health Sciences Pharmacology, Toxicology and Pharmaceutical Science Pharmacology
Preview
Repeated administration of phytocannabinoid Δ9-THC or synthetic cannabinoids JWH-018 and JWH-073 induces tolerance to hypothermia but not locomotor suppression in mice, and reduces CB1 receptor expression and function in a brain region-specific manner
Authors
S. Tai, W.S. Hyatt, C. Gu, L.N. Franks, T. Vasiljevik, L.K. Brents, P.L. Prather, W.E. Fantegrossi,
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Journal
Pharmacological Research
Journal: Pharmacological Research
Related Categories
CB1R
HU-210
CP-55,940
JWH-018
AM-2201
JWH-073
WIN-55,212-2
∆9-THC
[35S]GTPγS
∆9-tetrahydrocannabinol
Tolerance
Downregulation
Cross-tolerance
Cannabinoid
Desensitization
Drug Discovery
Pharmaceutical Science
Pharmacology
Pharmacology, Toxicology and Pharmaceutics (General)
Toxicology
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