Novel frontiers in calcium signaling: A possible target for chemotherapy

Intracellular calcium (Ca2+) is largely known as a second messenger that is able to drive effects ranging from vesicle formation to muscle contraction, energy production and much more. In spite of its physiological regulation, Ca2+ is a strategic tool for regulating apoptosis, especially during transmission between the endoplasmic reticulum and the mitochondria. Contact sites between these organelles are well-defined as signaling platforms where oncogenes and oncosuppressors can exert anti/pro-apoptotic activities. Recent advances from in vivo investigations into these regions highlight the role of the master oncosuppressor p53 in regulating Ca2+ transmission and apoptosis, and we propose that Ca2+ signals are relevant targets when developing new therapeutic approaches.