Interesting possibilities to improve the safety and efficacy of ipilimumab (Yervoy)

Left panel: Recalling Shakespeare's Taming of the shrew§ (§cf. CTLA-4 blockade): the central argument of this paper is that ipilimumab efficacy with safety can be improved by using a pretargeting approach worked out for radioimmunodetection and radioimmunotherapy (Scheme on the right). Color scheme panel (right): schematic of a three-step procedure: StAv-IgG is given first. After localizing to the tumor, a clearing agent that binds StAv-conjugate in the blood and recognized by hepatocytes is administered, targeting the conjugate to the liver for processing. Once the circulating conjugate is cleared, radiolabeled biotin is administered. Fig. 2 from Goldenberg DM et al. J Clin Oncol.2006;24:823-834. (Ref. [30] reproduced with permission); (Left panel: http://www.google.hu/search?q=taming+of+the+shrew&hl=hu&prmd=imvnsb&tbm=isch&tbo=u&source=univ&sa=X&ei=cvqgT-PEH8rftAb10sG5CA&ved=0CG0QsAQ&biw=1366&bih=667; http://www.google.com/intl/hu/permissions/).