| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5843858 | Pharmacological Research | 2011 | 7 Pages |
Abstract
- The central NPS-NPSR system plays no apparent role in normal GI motility.
- Central NPS inhibits colonic motility, affecting the stress-stimulated defecation in rats.
- The ability of NPS to inhibit stress-stimulated faecal output together with its anxiolytic effect is promising, IBS patients where the hyperactivity of the CRF system contributes to the co-morbidity of anxiety with colonic motor symptoms.
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Authors
Carla Petrella, Simona Agostini, Remo Guerrini, Girolamo Calò, Alessia Giaquinto, Chiara De Nuccio, Giovanna Improta, Maria Broccardo,