Acute administration of 3,4-methylenedioxymethamphetamine (MDMA) induces oxidative stress, lipoperoxidation and TNFÎ±-mediated apoptosis in rat liver

Article ID	Journal	Published Year	Pages	File Type
5843867	Pharmacological Research	2011	11 Pages	PDF

Keywords

TNB GPX Bcl-2 GSSG DTNB RNS IAPS IKK MDMA TdT CYP450 TRADD MPT MAT1 TNF-R1 SDS PAGE MDA A-SMase TRAF-2 Bax/Bak 5,5′-Dithio-bis (2-nitrobenzoic acid)LSAB second mitochondria-derived activator of caspases/direct IAP binding protein with low PI terminal deoxynucleotidyl transferase dUTP nick end labelling GST NF-κB GSH HSC TCA CAT NADPH BHT Jnk 3,4-methylenedioxymethamphetamine BSA c-Jun N-terminal kinase IκB kinase nicotinamide adenine dinucleotide (reduced form)ROS ATP Ascorbic acid bovine serum albumin acidic sphingomyelinase Smac/DIABLO trichloroacetic acid mitochondrial permeability transition RIPA buffer radioimmunoprecipitation assay buffer butylhydroxytoluene terminal deoxynucleotidyl transferase Oxidative stress tumor necrosis factor α TUNEL Apoptosis SOD Hepatic stellate cells Superoxide dismutase Cytochrome P450 TNF receptor-associated factor 2 TNF-α nuclear factor kappa B malondialdehyde inhibitor of apoptosis proteins NADH nicotinamide adenine dinucleotide phosphate-oxidase RIP Receptor interacting protein BID Catalase Liver Glutathione transferase glutathione reductase glutathione peroxidase Glutathione reduced reactive nitrogen species Reactive oxygen species tumor necrosis factor receptor

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Acute administration of 3,4-methylenedioxymethamphetamine (MDMA) induces oxidative stress, lipoperoxidation and TNFÎ±-mediated apoptosis in rat liver

Authors

D. Cerretani, S. Bello, S. Cantatore, A.I. Fiaschi, G. Montefrancesco, M. Neri, C. Pomara, I. Riezzo, C. Fiore, A. Bonsignore, E. Turillazzi, V. Fineschi,