| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5843919 | Pharmacology & Therapeutics | 2015 | 15 Pages |
Abstract
In this review, we offer a critical perspective analyzing the achievements using the most important strategies developed up till now: TGF-β antibodies, chemical inhibitors of TGF-β receptors, miRNAs and signaling pathways and BMP agonists with a potential role as therapeutic molecules against kidney fibrosis.
Keywords
ECMHSCsTβRIIGSCPAI-1TIFMEFTβRITGF-β1CTGF/CCN2UUOTGF-βPPAR-γMAPKmicro-ribonucleic acidUnilateral ureteral obstructionBambichronic kidney diseaseESRD یا end stage renal diseaseEnd-stage renal diseasetransforming growth factor-βEMTHepatic stellate cellsConnective tissue growth factormouse embryo fibroblastKidney fibrosisExtracellular matrixBMPplasminogen activator inhibitor 1InhibitorsMicro-RNAsMiRNACKDSmad proteinsBone morphogenetic proteinbone morphogenetic proteinsmitogen activated protein kinaseepithelial-to-mesenchymal transitionglomerulosclerosisPeroxisome proliferator-activated receptor-γ
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Authors
José M. Muñoz-Félix, MarÃa González-Núñez, Carlos MartÃnez-Salgado, José M. López-Novoa,