| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5843931 | Pharmacology & Therapeutics | 2015 | 23 Pages |
Abstract
This review will give an overview of the philosophical debate around the role of histones in controlling or modulating gene expression and discuss the most common techniques for histone profiling. In addition, we will provide prominent examples of aberrantly expressed or mutated chromatin modifiers that result in either globally or locally aberrant histone profiles, and that may be promising therapeutic targets.
Keywords
BRDRARαTrxKMTPcGME2HDACTrithoraxME1TSSme3PTMhMTatRAall-trans retinoic acidAcetylPost translational modificationBromodomainTherapyRetinoic acidtranscription start siteCancerTranscription factorFollicular lymphomaLysinelysine methyltransferaseMethylHistoneHistone acetyltransferasehistone deacetylaseHistone MethyltransferaseChromatinHATpolycomb group
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Pharmacology
Authors
Simone S. Riedel, Tobias Neff, Kathrin M. Bernt,