Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5843988 | Pharmacology & Therapeutics | 2015 | 9 Pages |
Abstract
The Bcl-2 family of proteins serves as primary regulators of apoptosis. Myeloid cell leukemia 1 (Mcl-1), a pro-survival member of the Bcl-2 family of proteins, is overexpressed and the Mcl-1 gene is amplified in many tumor types. Moreover, the overexpression of Mcl-1 is the cause of resistance to several chemotherapeutic agents. Thus, Mcl-1 is a promising cancer target. This review highlights the current progress on the discovery of small molecule Mcl-1 inhibitors.
Keywords
Bcl-xLBH3Bcl-2 homologous antagonist/killerBcl-2 homology domain 3Bcl-2 associated XSARBfl-1/A1Bcl-2Mcl-1phorbol-12-myristate-13-acetate-induced protein 1Myeloid cell leukemia-1p53 upregulated modulator of apoptosisNoxaBaxBADtBidSurface plasmon resonanceSPRStructure activity relationshipsB-cell lymphoma-2B-cell lymphoma-extra largeBIMBcl-2-associated death promoterInhibitorsSmall moleculeBcl-2 homologyBAKPUMA
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Authors
Johannes Belmar, Stephen W. Fesik,