Alcoholic and non-alcoholic steatohepatitis

Article ID	Journal	Published Year	Pages	File Type
5888115	Experimental and Molecular Pathology	2014	19 Pages	PDF

Abstract

The integrative symposia investigate different aspects of alcohol-induced liver damage and possible repair. We aim to (1) determine the immuno-pathology of alcohol-induced liver damage, (2) examine the role of genetics in the development of ASH, (3) propose diagnostic markers of ASH and NASH, (4) examine age differences, (5) develop common research tools to study alcohol-induced effects in clinical and pre-clinical studies, and (6) focus on factors that aggravate severity of organ-damage. The intention of these symposia is to advance the international profile of the biological research on alcoholism. We also wish to further our mission of leading the forum to progress the science and practice of translational research in alcoholism.

Keywords

γGT USF CyP CDT SAM MDF Maddrey discriminant function Lactobacillus rhamnosus GG ALT HFD ADH S-adenosylhomocysteine Hepatocarcinogenesis TLR CYP2E1 SAH GAA MEOS MCV LGG PTU Laboratory markers NAFLD TNF MMP LPS IGF Propylthiouracil 4-HNE MDB Mallory–Denk body 4-hydroxynonenal HCC ROS ALD AST Aspartate aminotransferase Alanine aminotransferase nonalcoholic steatohepatitis Linoleic acid Alcohol dehydrogenase MRI Carbohydrate-deficient transferrin Immunohistochemistry interleukin alcoholic liver disease non-alcoholic fatty liver disease Magnetic resonance imaging toll like receptor Ash Hangover High fat diet TIMP Cytochrome P450 microsomal ethanol oxidizing system Insulin-like growth factor tumor necrosis factor lipopolysaccharide matrix metalloprotein Methylation Model for End-Stage Liver Disease Tissue inhibitor of metalloproteinase Mitochondrion Micronutrients Nash Alcoholic hepatitis acute alcoholic hepatitis Hepatitis C virus HCV Viral hepatitis human immunodeficiency virus Unsaturated fat saturated fat Hepatocellular carcinoma Gamma glutamyl transpeptidase MELD Guanidinoacetate Reactive oxygen species