Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5888215 | Experimental and Molecular Pathology | 2013 | 9 Pages |
Abstract
⺠Metaloproteinase-2 (MMP-2) is relevant in hypertensive cardiac remodeling. ⺠Oxidative stress and transforming growth factor-β (TGF-β) affect MMP activity. ⺠We show temporal alterations in these factors during hypertension. ⺠Hypertension upregulated MMP-2, TGF-β, and promoted oxidative stress. ⺠These alterations were found at early and late phases of hypertension.
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Authors
Elen Rizzi, Carla S. Ceron, Danielle A. Guimaraes, Cibele M. Prado, Marcos A. Rossi, Raquel F. Gerlach, Jose E. Tanus-Santos,