| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5898130 | Cytokine | 2011 | 7 Pages |
Abstract
⺠We discuss the expression patterns, source of IL-21/IL-21R in healthy cells. ⺠We discuss the JAK/STAT signal transduction pathways, especially STAT3. ⺠Expression of IL-21/IL-21R and its effect in hematological malignancies are discussed in individual sections. ⺠IL-21 regulates proliferation, survival or apoptosis of hematological malignancies, depending on the neoplastic cell type.
Keywords
CpGTNFIL-21 receptorGAL1IL-21RIL-21TNFRHTLV-INF-kappaBMIP-3αoligodeoxynucleotideODNIGF-1JAK/STATinsulin-like growth factor-1EBVInterleukin-21Hematological malignanciesImmune therapyCytosine-phosphate-guanosinetumor necrosis factornuclear factor-kappaBEpstein-Barr virushuman T-cell leukemia virus type Itumor necrosis factor receptor
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Authors
Jingjing Ma, Daoxin Ma, Chunyan Ji,