HSM - a hybrid system based approach for modelling intracellular networks

We apply our model and analysis methods to a well-studied gene network of λ-phage. The phage has two well-known qualitatively different behaviours - lysis and lysogeny. We show that our model has an attractor structure that corresponds well to these two behaviours and that these are the only stable behaviours that can be exhibited by the system. The algorithm also generates (in principle biologically verifiable) hypotheses about the mutations of λ-phage that should change its observable behaviour.