Preparation and in vivo evaluation of ligand-conjugated polymeric microbubbles as targeted ultrasound contrast agents

- The polymeric microbubbles show narrow average size and size distribution.
- The carboxyl groups on the polymeric microbubbles surface were activated by EDC/NHS.
- The microbubbles can locate on inflamed plaque by modifying the surface with ligand.
- The high conjugation efficiency makes the microbubbles use in clinical applications.
- The targeted microbubbles have a significant ultrasound contrast-enhanced property.