Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5931028 | The American Journal of Cardiology | 2013 | 4 Pages |
Abstract
Pulmonary oxygen uptake (VËO2p) at exercise onset is severely delayed in heart transplant recipients (HTRs). The role of exercise training to improve VËO2p kinetics in HTRs has not been studied. We examined VËO2p kinetics before and after 12 weeks of aerobic and strength training (HTR-T; n = 19, mean ± SD age: 57 ± 10 years) or usual care (HTR-UC; n = 16, mean age: 58 ± 12 years). Phase II VËO2p kinetics, reflecting the rate of muscle metabolic adaptation, improved 37% after training compared with usual care (HTR-UC, 15 ± 19 vs 2 ± 13 seconds improvement, p = 0.02). The change in rest to steady-state heart rate reserve before and after 12 weeks was not different in HTR-T (â2 ± 9 beats/min) and HTR-UC (â1 ± 7 beats/min; p = 0.78). No significant relation was found between the change in VËO2p kinetics and rest to steady-state heart rate reserve. Changes in leg lean tissue mass and VËO2p kinetics were significantly related (r = â0.46, p = 0.008). In conclusion, a favorable adaptation in skeletal muscle oxidative function may underpin our finding of faster VËO2p kinetics in HTRs after exercise training.
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Authors
Corey R. PhD, Wayne J. MD, Mark J. PhD,