| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 593756 | Colloids and Surfaces A: Physicochemical and Engineering Aspects | 2013 | 8 Pages |
Vesicles constructed by supramolecular amphiphiles are considered as more promising stimuli-responsive vehicles for carrying and delivering targeted molecules. In this research, novel supramolecular amphiphiles are directly assembled from UR-144, a general neuropathic drug, and a class of mono-diaminoalkane substituted β-cyclodextrins. In the aqueous solution, the supramolecular amphiphiles can assemble into vesicular particles, which were characterized in detail by transmission electron microscopy (TEM), atomic force microscopy (AFM), scanning electron microscopy (SEM) and dynamic light scattering (DLS). The mechanism was also suggested based on the NMR, Fourier transform infrared spectroscopy (FT-IR) and X-ray diffraction (XRD) experimental results. The vesicular particles tend to be damaged upon the addition of Cu2+ and meanwhile release UR-144.
Graphical abstractThe king is also a royal-palanquin lifter.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► The idea of directly using drugs to construct vesicular structures was posed. ► Vesicular particles were obtained from the complex of cyclodextrin/UR-144. ► The mechanism of the vesicular formation was proposed. ► Cu2+-triggered release of UR-144 was achieved.
