| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 594534 | Colloids and Surfaces A: Physicochemical and Engineering Aspects | 2011 | 8 Pages |
Fabrication of vesicles with the diameter of 4–30 μm was achieved by mixing hydrophobic nonionic surfactant (Span 65) with a poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymer (Pluronic P123) in aqueous solutions at room temperature. Ring-shaped structure of the Pluronic P123/Span 65 mixture assemblies was confirmed by fluorescence microscopy. The presence of internal aqueous phase in the Pluronic P123/Span 65 mixture assemblies was determined by measuring the entrapment efficiency of calcein using fluorescence spectroscopy. On the other hand, Pluronic P123/Span 60 mixture system formed wire-like assemblies but not vesicles.
Graphical abstract.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Vesicle formation from Pluronic P123/Span 65 mixture in water. ► Wire-like assemblies formed from Pluronic P123/Span 60 mixture in water. ► Ring-shaped structure of Pluronic P123/Span 65 mixture assemblies observed by fluorescence microscopy. ► Wire-like assemblies of Pluronic P123/Span 60 mixture observed by cryo-transmission electron microscopy. ► Internal aqueous phase of Pluronic P123/Span 65 mixture vesicles confirmed by measuring the entrapment efficiency of calcein.
