| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 594580 | Colloids and Surfaces A: Physicochemical and Engineering Aspects | 2011 | 4 Pages |
A general approach to endow gold nanoshells a new function of controlled release was established by coating stimulus-responsive polymers on their surfaces via surface-initiated atom transfer radical polymerization. Incorporating boronic acid groups in polymer brushes, the controlled release of Alizarin Red S (ARS) was dynamically shown, through reversible covalent binding between boronic acid and diol.
Graphical abstract. Gold nanoshells coated with polymer brushes, PMAA and PNIPAAM-co-PMAA, show saccharide- and temperature-responsive diol releases by incorporating boronic groups. This multifunctional nanomaterial provides a core for bioimaging and a shell for drug release.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► PNIPAAM-co-PMAA polymer brushes were fabricated on gold nanoshells (AuNS) via SI-ATRP. ► Modify the hybrids of AuNS@PNIPAAM-co-PMAA with boronic acid to be drug carriers. ► Controlled releases were performed in vitro under saccharide substitution and temperature enhancement.
